Linpiyawan 2000.

Methods	Location of study: Thailand Loss to follow‐up: none Analysis: ITT
Participants	Inclusion criteria: oropharyngeal candidiasis, AIDS patients Exclusion criteria: treatment with any antifungal agent 2 weeks prior to study entry; pregnancy; breastfeeding; significant liver disease 29 enrolled Clotrimazole group = 15 Itraconazole group = 14 diagnosis confirmed using KOH and culture
Interventions	Clotrimazole troche 10mg five time daily Itraconazole oral soln 100mg/10ml twice daily Duration: 1 week
Outcomes	Clinical evaluation ‐ assessed by scoring method (0‐3, absent to severe) Mycological assessment ‐ KOH prep and fungal culture Global evaluation ‐ cure (all signs and symptoms resolved with no evidence of infection) ‐ improvement (decrease in clinical score without complete resolution) ‐ failure (lack of improvement or further deterioration) Adverse events: 2 patients had transient elevation of liver enzymes
Notes	Ethics: none mentioned No table with demographics. Mention in text that groups are comparable. Author contacted, no response to date 24/08/2004 Author contacted via email: 27/9/2004; 27/10/2004 ‐ no response by 08/11/2004
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Random allocation ‐ does not mention method used.
Allocation concealment?	High risk	Not reported
Blinding? All outcomes	Unclear risk	"...observer blinded..."
Incomplete outcome data addressed? All outcomes	Low risk	No Loss to follow‐up