Nittayananta 2008.

Methods	Study conducted in Thailand with participants those who lived at Wiwekwanasom temple, or were outpatients at an internal medicine unit at Songklanagarind Hospital in Songkhla province in the south, of at Bamratnaradoon Institute in Nonthaburi, Thailand. Loss to follow‐up: Not reported Analysis: no ITT
Participants	Inclusion criteria: HIV‐infected heterosexual adults previously diagnosed as seropositive for antibodies to HIV. Presented with oral candidiasis. No current use or history of antifungal therapy last 3 months. Able to use mouth‐rinse properly. Able to come for follow‐up visits for at least a 3‐month period after complete treatment of OC. Willing to provide informed consent. Exclusion criteria: HIV‐seropositive without OC or with diabetes, history of organ transplantation, or any other immunosuppressive disease. Any current treatment of history of taking antifungals in last 3 months. 102 enrolled ‐ Chlorhexadine: 37 (aged 22 ‐ 52 years, mean 34 years) ‐ Normal saline: 38 (aged 22 ‐ 55 years, mean 38 years) Diagnosis confirmed: Yes ‐ oral rinse to determine CFU
Interventions	0.12% chlorhexidine mouth‐rinse 0.9% normal saline
Outcomes	Primary: Prevention of relapse after antifungal therapy
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Not reported
Allocation concealment?	Unclear risk	Not reported
Blinding? All outcomes	Low risk	Double‐blind, but unclear who was blinded
Incomplete outcome data addressed? All outcomes	Unclear risk	Loss to follow up not reported.