Redding 1992.

Methods	Study conducted in USA, no dates provided. Loss to follow‐up: none during treatment Analysis: ITT
Participants	Eligibility criteria: HIV positive adults with thrush; subjective complaints of oral discomfort Exclusion criteria: Other anti‐fungals within 3 days before enrolment; pregnancy; breastfeeding; life expectancy < 4 weeks Diagnosis confirmed: yes ‐ KOH preparation/gram stain; positive culture 24 patients Fluconazole‐13 Clotrimazole‐11
Interventions	Fluconazole 100mg tablets once per day Clotrimazole 10mg troches five times per day Duration: 14 days Clinically cured patients followed‐up for relapse at d28 and d42
Outcomes	Clinical cure: defined as absence of lesions Colonisation: Positive culture of clinically cured Relapse Adverse events: nausea; flatulence
Notes	Ethics: no mention No demographics reported Author contacted, no response to date 24/08/2004 Author contacted via email: 08/11/2004 (age groups) Location of study: USA
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk	Computer generated
Allocation concealment?	Unclear risk	Not reported
Blinding? All outcomes	Low risk	Single‐blind: clinician blinded
Incomplete outcome data addressed? All outcomes	Unclear risk	ITT analysis.