Wright 2009.

Methods	Single Centre study conducted at the Moretele Hospice, South Africa Study period: 10 days Loss to follow‐up: Gentian Violet: 12 withdrawn; 1 incomplete data Lemon juice: 12 withdrawn Lemon Grass: 6 withdrawn; 6 incomplete data Analysis: ITT as well as analysis of only those who completed study.
Participants	Inclusion criteria: HIV+; positive diagnosis of oral thrush; currently not on any medication for oral thrush; willing to participate Exclusion criteria: Patients who did not have thrush at the time of the study. Patiens not expected to remain alive for the study period of 10 days. Grading and diagnosis of oral thrush according to Oral thrush scale. 90 patients enrolled and randomised. Gentian violet: 30 Lemon juice ‐ 30 Lemon grass ‐ 30 Duration: 10 days.
Interventions	Gentian violet: 0.5% aqueous solution Lemon juice:20 ml lemon juice diluted with 10 ml water; 2‐3 drops 3 times per day Lemon grass: 12.5ml dried lemon grass in 500 ml boiling water. Drink 125 ml first day and thereafter 250 ml daily
Outcomes	Clinical success Clinical failure Adverse events reported: Gentian Violet: purple discolouration, cracked lips and dry mouth Lemon juice: changed taste in mouth and abdominal cramps Lemon grass: increased appetite
Notes	Ethics: Signed informed consent before participation.
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Random allocation, but method of sequence generation not reported
Allocation concealment?	Low risk	Identical, sealed, opaque, sequentially numbered envelopes.
Blinding? All outcomes	High risk	Nothing reported regarding blinding. Difficult to blind gentian violet.
Incomplete outcome data addressed? All outcomes	Low risk	Analysis ITT as well as analysis of only those who completed study.