Table 1.

Cancer‐associated DNA binding proteins

Cancer	DNA binding protein	Function	Reference
AML	MLL‐AEP	Immortalization of hematopoietic progenitors	8
AML	AML1‐ETO	G1 cell cycle progression	34
CML	Fox3a	Acquisition of resistance to imatinib	59
Breast cancer	c‐Myc	Upregulation of mitotic‐associated genes	36
Breast cancer	SOX2	Induction of tamoxifen resistance	37
Melanoma	DUX4	Immune invasion through the downregulation of MHC class I	38
Glioma	TRF1	Telomeric damage and inhibition of CSC properties	60
Colon	TRF2	Induction of endothelial cell differentiation and angiogenesis	30

Each DNA binding protein is associated with tumor malignancies.

AEP, AF4 family/ENL family/P‐TEFb; CSC, cancer stem cell; DUX4, double homeobox protein 4; ETO, eight‐twenty one; MLL, mixed‐lineage leukemia; SOX2, Sry‐related high‐mobility box 2; TRF1, telomere‐repeat binding factor 1.