Figure 1.

Protease‐activated receptor‐2 (PAR‐2) deficiency improved the health of Apc ^Min/+ mice deficient in intestinal hepatocyte growth factor activator inhibitor‐1 (HAI‐1). A, Relative body weight (mean ± SEM) of Spint1^LoxP/LoxP/Apc ^Min/+ mice (HAI‐1 control [cont] + PAR‐2 cont) (n = 11), Spint1^LoxP/LoxP/F2rl1 ^−/−/Apc ^Min/+ mice (HAI‐1 cont + PAR‐2 knockout [KO]) (n = 11), Spint1^LoxP/LoxP/Villin‐Cre/Apc ^Min/+ mice (HAI‐1 KO + PAR‐2 cont) (n = 10), and Spint1^LoxP/LoxP/Villin‐Cre/F2rl1 ^−/−/Apc ^Min/+ mice (HAI‐1 KO + PAR‐2 KO) (n = 11). B, Mean hemoglobin concentration (left panel) and hematocrit levels (right panel) of the mice. Box and whiskers indicate the interquartile range and sample maxima and minima, respectively. Median is indicated by a bold line