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Model of proposed molecular mechanism underlying angiopoietin‐like protein 2 (ANGPTL2)‐mediated metabolic reprogramming. In lung cancer cells, tumor cell‐derived ANGPTL2 activates the transforming growth factor‐β (TGF‐β)‐zinc finger E‐box binding homeobox 1 (ZEB1) pathway through integrin α5β1‐ERK and induces not only the epithelial‐mesenchymal transition (EMT) but also glucose transporter 3 (GLUT3) expression, enhancing glycolytic metabolism
