Figure 2.

MicroRNA (miR)‐302/367 cluster participates in the regulation of cell stemness. The miR‐302/367 cluster controls the stemness of human embryonic stem cells, induced pluripotent stem cells, and cancer stem cells by regulating pluripotent differentiation, G₁‐S phase transition, and self‐renewal. The 3 major regulatory pathways are connected by nodal proteins such as AKT and organic cation/carnitine transporter 4 (OCT4). MYC, P21, cyclin D (CCND), and β‐catenin are important in intracellular signaling networks in cancer. P21 and CCND are representative molecules involved in cytostasis and differentiation. Myc is a classical member of the proliferation and motility signaling networks. BMI, B cell‐specific Moloney murine leukemia virus integration site 1; CCNE, cyclin E; CDK, cyclin‐dependent kinase; E2F7, E2F transcription factor 7; Klf4, Kruppel like factor 4; NR2F2, nuclear receptor subfamily 2 group F member 2; SOX2, SRY‐box transcription factor 2