Crespi 2008.
| Methods | Trial Design: randomised, parallel group trial Location: Milan, Italy Number of centres: one ("Vita Salute" University, San Rafaele Hospital) Recruitment period: not stated Funding source: not stated |
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| Participants | Inclusion criteria: patients rehabilitated with single implants in maxillary (premolar to premolar) fresh extraction sockets with 4 bony walls and at least 4 mm of bone beyond the root apex and the presence of adjacent teeth Exclusion criteria: presence of dehiscence or fenestration of the residual bony walls, signs of acute infection around the alveolar bone at the implant site, bruxism, patients smoking more than 10 cigarettes a day, uncontrolled diabetes, coagulation disorders, alcohol or drug abuse Age at baseline: mean 47.21 years (24‐68 years) Gender: M16/F24 Number randomised: 40 Number evaluated: 40 |
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| Interventions |
Comparison: Immediate versus conventional loading Gp A (n = 20) Immediate loading: 13 mm long single implants loaded immediately (the same day) Gp B (n = 20) Conventional loading: 13 mm long single implants loaded conventionally at 3 months Outlink (Sweden & Martina, Padova, Italy) titanium solid screws were used Duration of follow‐up: 2 years |
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| Outcomes | Prosthesis/implant failures, marginal bone level changes on periapical radiographs 1‐year data used |
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| Notes | Sample size calculation: not reported | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Reported in the article: "All patients required a single‐tooth extraction for root fractures, caries or endodontic reasons, or periapical disease and were randomly assigned to the test or control group" No reply to letter |
| Allocation concealment (selection bias) | Unclear risk | Nothing reported in the article No reply to letter |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Nothing reported in the article No reply to letter |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | All data presented |
| Selective reporting (reporting bias) | Low risk | All outcomes appear to be presented |
| Other bias | Low risk | None detected |