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. 2009 Jan 21;2009(1):CD003799. doi: 10.1002/14651858.CD003799.pub2

Comparison 4. Speed of information processing and concentration tests.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 TMT‐A after 1 month with 1.25 mg CEE or placebo 1 40 Mean Difference (IV, Fixed, 95% CI) ‐31.52 [‐70.40, 7.36]
2 TMT‐A after > 2 months HRT or placebo 4 165 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.08 [‐0.39, 0.24]
2.1 TMT‐A (time) after 2 months with E2 transdermal or placebo 1 12 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.22 [‐1.36, 0.91]
2.2 TMT‐A (time) after 4‐12 months with (0.625 mg + 1.25 mg) CEE or placebo 2 133 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.01 [‐0.37, 0.34]
2.3 TMT‐A (lines/sec, reversed) after 9 months with 0.625 mg CEE + MPA or placebo 1 20 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.40 [‐1.29, 0.49]
3 TMT‐B after 1 month with CEE or placebo 1 36 Mean Difference (IV, Fixed, 95% CI) ‐40.9 [‐79.29, ‐2.51]
4 TMT‐B after > 2 months 2 56 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.21 [‐0.74, 0.32]
4.1 TMT‐B after 4 months with 1.25 mg CEE or placebo 1 36 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.33 [‐0.98, 0.33]
4.2 TMT‐B after 9 months with 0.625 mg CEE + MPA or placebo 1 20 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [‐0.88, 0.88]
5 Stroop after 2 months with E2 transdermal or placebo 2 32 Std. Mean Difference (IV, Random, 95% CI) ‐0.20 [‐0.90, 0.49]
6 DSST after 12 months with (0.625 mg + 1.25 mg) CEE or placebo 1 97 Mean Difference (IV, Fixed, 95% CI) 0.5 [‐2.51, 3.51]
7 Letter Cancellation test after 12 months with (0.625 mg + 1.25 mg) CEE or placebo 1 97 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐2.74, 2.54]
8 Finger tapping after 12 months with (0.625 mg + 1.25 mg) CEE or placebo 1 97 Mean Difference (IV, Fixed, 95% CI) ‐3.9 [‐7.85, 0.05]
9 Digit Span backwards after 1 month of 1.25 mg CEE or placebo 1 40 Mean Difference (IV, Fixed, 95% CI) 0.76 [‐0.37, 1.89]
10 Digit Span backwards after > 4 months of CEE 2 54 Std. Mean Difference (IV, Fixed, 95% CI) 0.43 [‐0.12, 0.97]
10.1 Digit span after 4 months with 1.25 mg CEE or placebo 1 36 Std. Mean Difference (IV, Fixed, 95% CI) 0.67 [‐0.01, 1.34]
10.2 Digit Span after 9 months with 0.625 mg CEE + MPA or placebo 1 18 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.02 [‐0.94, 0.90]