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. 2009 Jan 21;2009(1):CD003799. doi: 10.1002/14651858.CD003799.pub2

Zhang 2006.

Methods Design: 
 randomised, double‐blind, parallel groups
4 months
Participants Country: China 
 n=41 mild AD (DSM‐IV) 
 Aged 47‐62 (55 +/‐0.4) years 
 All menopause before age 65 
 Exclusion:dementia due to 'vessel, infection, toxication, metabolism, liver/kidney dysfunction or depression. All gave informed consent and had CT/MRI
Interventions 1. Beimeili (conjugated estrogen, Wyeth, USA) oral/1.25 mg /day 
 2. vit B1 20 mg 3x/day as Placebo
Outcomes General Hasegawa Dementia Scale‐R (HDS‐R) 
 ADL
Notes HRT > vitamin B1 after 4 months on HDS‐R and ADL