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. 2020 Apr 8;12:90. doi: 10.3389/fnagi.2020.00090

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Copyright © 2020 Zheng, Onoda, Nagai and Yamaguchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Lateral and medial views of mean maps of sample entropy for scales 1–6. The value range was different for each scale. (B) Mean sample entropy of the whole brain for scales 1–6. Error bar denotes standard deviation. (C) Group comparisons of sample entropy using whole-brain ANCOVA. Top: Brain regions displayed significant main effects of group (voxel level p < 0.001 and cluster level false-discovery rate corrected p < 0.05). Bottom: Violin plot of each individual sample entropy value. Boxes indicate the mean and interquartile. Whiskers indicate the interquartile range. NC, normal control; EMCI, early mild cognitive impairment; LMCI, late mild cognitive impairment.