Kicklighter 2001.

Methods	Randomised placebo‐controlled trial
Participants	103 VLBW infants < 3 days old Infants with evidence of liver failure, congenital heart disease, or congenital defects needing surgery were not eligible for inclusion
Interventions	Fluconazole 6 mg/kg (N = 53) or placebo (N = 50) every third day for one week than daily for three more weeks. Administered intravenously and then oro‐gastrically when tolerated
Outcomes	Fungal colonisation and invasive infection Emergence of fluconazole resistance Adverse drug reactions Death prior to hospital discharge
Notes	Setting: Medical University of South Carolina; 1998 to 1999
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	Random assignment by separate trials centre
Blinding (performance bias and detection bias) All outcomes	Low risk	Placebo‐controlled
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Placebo‐controlled
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Placebo‐controlled
Incomplete outcome data (attrition bias) All outcomes	Low risk	Complete follow‐up