Manzoni 2007b.

Methods	Randomised controlled trial
Participants	216 VLBW infants
Interventions	Fluconazole 3 mg/kg (N = 104) versus 6 mg/kg (N = 112) given every second day from birth for 30 days (or 45 days for ELBW infants (N = 216))
Outcomes	Fungal colonisation and invasive infection Death prior to hospital discharge Emergence of fluconazole resistance
Notes	Setting: Eight level III neonatal units in Turin, Rome, Milan, or Pavia, Italy (2004 to 2006) Manzoni 2007b is the internal dose comparison of Manzoni 2007a intervention group
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	Computer‐generated and allocated
Blinding (performance bias and detection bias) All outcomes	Low risk	Placebo‐controlled
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Placebo‐controlled
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Placebo‐controlled
Incomplete outcome data (attrition bias) All outcomes	Low risk	Complete follow‐up