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. 2010 Jan 20;2010(1):CD003974. doi: 10.1002/14651858.CD003974.pub3

Roscoe 2005.

Methods Design: three group parallel trial 
 Purpose: examine the effect of acustimulation on chemotherapy‐induced nausea in women with breast cancer
Participants Patients: patients about to receive their second chemotherapy treatment who experienced nausea or vomiting after the first treatment
Interventions Placebo: acustimulation wrist‐band without stimulation 
 Untreated: no acustimulation wrist band 
 Experimental: acustimulation wrist band with stimulation 
 (Co‐intervention: standard clinical antiemetic prophylaxis, including a 5‐HT3 receptor antagonist)
Outcomes Acute nausea (7‐point scale) 
 Delayed nausea 
 Vomiting 
 Quality of life 
 Antiemetic medication
Notes SE values were provided in the original publication and these values were converted to SDs.
Risk of bias
Bias Authors' judgement Support for judgement
Adequate sequence generation? Unclear risk NS
Allocation concealment? Unclear risk NS
Blinding? 
 Treatment provider Unclear risk NS
Blinding? 
 Outcome assessor Unclear risk Not relevant as patient reported outcome
Incomplete outcome data addressed? 
 All outcomes Low risk Drop‐out < 15%
Free of selective reporting? Unclear risk No protocol available
Free of other bias? Low risk  
No signs of variance inequality or skewness? Low risk No variance inequality (F‐test not statistically significant) and no skewness (1.64 standard deviations does not exceed the mean)
Trial size > 49? Low risk N = 64
Clearly concealed allocation + trial size > 49 + drop‐out max 15% High risk Allocation not clearly concealed