| Methods |
Design: three group parallel trial
Purpose: examine the effect of pseudocatalase cream and placebo on repigmentation in vitiligo |
| Participants |
Patients: out‐patients with vitiligo
Baseline comparability: NS |
| Interventions |
Placebo: cream with no pseudocatalase
Untreated: no cream
Experimental: cream with pseudocatalase
(Co‐intervention: climatotherapy) |
| Outcomes |
No or minimal repigmentation (photographs graded 0 to 3) |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
NS |
| Allocation concealment? |
Unclear risk |
NS |
| Blinding?
Treatment provider |
Unclear risk |
NS |
| Blinding?
Outcome assessor |
Unclear risk |
NS |
| Incomplete outcome data addressed?
All outcomes |
High risk |
Drop‐out > 15% or NS |
| Free of selective reporting? |
Unclear risk |
No protocol available |
| Free of other bias? |
Low risk |
|
| No signs of variance inequality or skewness? |
Unclear risk |
Not relevant (binary outcome) |
| Trial size > 49? |
High risk |
N = 20 |
| Clearly concealed allocation + trial size > 49 + drop‐out max 15% |
High risk |
Trial size < 49 |
