| Methods |
Design: three group parallel trial
Purpose: examine the prophylactic effect of penicillin on post treatment symptoms following root canal treatment for asymptomatic periapical pathosis |
| Participants |
Patients: out‐patients undergoing root canal treatment
Baseline comparability: NS |
| Interventions |
Placebo: tablets without penicillin
Untreated: no tablets
Experimental: tablets with penicillin
(Co‐intervention: NS) |
| Outcomes |
Number of patients in pain
Swelling
Side effects |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Blinding?
Treatment provider |
High risk |
Not described as double‐blind |
| Blinding?
Outcome assessor |
Unclear risk |
Not relevant as patient reported outcome |
| Incomplete outcome data addressed?
All outcomes |
High risk |
|
| Free of selective reporting? |
Unclear risk |
No protocol available |
| Free of other bias? |
Low risk |
|
| No signs of variance inequality or skewness? |
Unclear risk |
Not relevant (binary outcome) |
| Trial size > 49? |
Low risk |
N = 54 |
| Clearly concealed allocation + trial size > 49 + drop‐out max 15% |
High risk |
|
