| Methods |
Design: three group parallel trial
Purpose: examine the effect of disulfiram and placebo implants on alcoholism |
| Participants |
Patients: alcoholics
Baseline comparability: NS |
| Interventions |
Placebo: implants without disulfiram
Untreated: no implants
Experimental: implants with disulfiram
(Co‐intervention: NS) |
| Outcomes |
Number of abstinent drinkers
Mean time to first alcoholic consumption |
| Notes |
Patients were randomised to placebo and no treatment in a 4:1 ratio |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Blinding?
Treatment provider |
Low risk |
'Assignment to the disulfiram and placebo conditions was double‐blind' |
| Blinding?
Outcome assessor |
Unclear risk |
Not relevant as patient reported outcome |
| Incomplete outcome data addressed?
All outcomes |
High risk |
|
| Free of selective reporting? |
Unclear risk |
No protocol available |
| Free of other bias? |
Low risk |
|
| No signs of variance inequality or skewness? |
Unclear risk |
Not relevant (binary outcome) |
| Trial size > 49? |
Low risk |
N = 50 |
| Clearly concealed allocation + trial size > 49 + drop‐out max 15% |
High risk |
|
