| Methods |
Design: three group parallel trial
Purpose: examine the effect of adenine arabinoside on episodes of genital herpes |
| Participants |
Patients: out‐patients with episodes of genital herpes
Baseline comparability: NS |
| Interventions |
Placebo: ointment or gel without adenine arabinoside
Untreated: no ointment or gel
Experimental: ointment or gel with adenine arabinoside
(Co‐intervention: NS) |
| Outcomes |
Pain
Mean duration of pain
Mean duration of viral shedding
Mean duration of lesions
Mean duration any new lesion during treatment |
| Notes |
Relevant outcome data not reported in article |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
NS |
| Allocation concealment? |
Unclear risk |
NS |
| Blinding?
Treatment provider |
Low risk |
'Thus ara‐A or placebo ointment or gel were given in a double‐blind fashion' |
| Blinding?
Outcome assessor |
Unclear risk |
NS |
| Incomplete outcome data addressed?
All outcomes |
High risk |
Drop‐out > 15% or NS |
| Free of selective reporting? |
High risk |
Relevant outcome data not reported in article |
| Free of other bias? |
Low risk |
|
| Trial size > 49? |
High risk |
N = 38 |
| Clearly concealed allocation + trial size > 49 + drop‐out max 15% |
High risk |
Trial size < 49 |
