Table II.
Change in symptom control ≥minimum important difference for study population (and by severity definition) where this resulted in a change in symptom control from well controlled to suboptimal (or vice versa)
| Population | n | Improved | No change | Worse | McNemar P value |
|---|---|---|---|---|---|
| Complete cohort | |||||
| All ages | 319 | 28 (9) | 254 (80) | 37 (12) | .26 |
| 2-4 y | 60 | 3 (5) | 49 (82) | 8 (13) | .13 |
| 5+ y | 259 | 25 (10) | 205 (79) | 29 (11) | .59 |
| “Persistent poor control” | |||||
| All ages | 147 | 12 (8) | 118 (80) | 17 (12) | .35 |
| 2-4 y | 45 | 3 (7) | 37 (82) | 5 (11) | .48 |
| 5+ y | 102 | 9 (9) | 81 (79) | 12 (12) | .51 |
| High-dose ICS | |||||
| All ages | 127 | 8 (6) | 106 (83) | 13 (10) | .26 |
| 2-4 y | 33 | 2 (6) | 29 (88) | 2 (6) | 1.00 |
| 5+ y | 94 | 6 (6) | 77 (82) | 11 (12) | .23 |
| “Difficult asthma” | |||||
| All ages | 90 | 7 (8) | 79 (88) | 4 (4) | .37∗ |
| 2-4 y | 37 | 3 (8) | 30 (81) | 4 (11) | .71 |
| 5+ y | 53 | 4 (8) | 49 (92) | 0 (0) | .05∗ |
Values are n (%).
∗
This severity definition is partially dependent on the (c)ACT score, so this P value may be influenced by regression to the mean.