Table III.
Delayed AEs occurring up to 72 hours after LAIV immunization, as reported by parents from 440 children with 72-hour follow-up
| AE | No. of children | Rate (95% CI) in this cohort |
|---|---|---|
| Upper respiratory tract | ||
| Upper respiratory tract (any) | 55 | 12.5% (9.6%-16.0%) |
| Isolated symptoms only, <24-h duration | 23 | 5.2% (3.3%-7.7%) |
| Isolated symptoms only, >24-h duration | 31 | 7.1% (4.8%-9.9%) |
| Nasal symptoms with ocular involvement | 1 | 0.2% (0.1%-1.3%) |
| Lower respiratory tract | ||
| Lower respiratory tract (any) | 56 | 12.7% (9.8%-16.2%) |
| Parent-reported wheeze | 28 | 6.4% (4.3%-9.1%) |
| Constitutional | ||
| Any | 58 | 13.2% (10.2%-16.7%) |
| Fever <24 h | 10 | 2.3% (1.1%-4.1%) |
| Fever >24 h | 7 | 1.6% (0.6%-3.3%) |
| Other: lethargy, headache, dizziness, myalgia | 42 | 9.6% (7.0%-12.7%) |
| Dermatological | ||
| Flare in eczema | 3 | 0.7% (0.1%-2.0%) |
| Nonspecific rash, no response to antihistamine | 5 | 1.1% (0.4%-2.6%) |
| Abdominal symptoms | ||
| Vomiting, nausea, abdominal pain | 9 | 2.1% (0.9%-3.9%) |
| Loose stools | 2 | 0.5% (0.1%-1.6%) |
| Ear-nose-throat | ||
| Mild nose bleed | 3 | 0.7% (0.1%-2.0%) |
| Sore throat | 4 | 0.9% (0.3%-2.3%) |
| Ocular | ||
| Itch, redness | 1 | 0.2% (0.01%-1.3%) |
| Neurological | ||
| Any | 0 | 0% (0.0%-0.8%) |
| Cardiovascular | ||
| Any | 0 | 0% (0.0%-0.8%) |