Table E2.
Change in symptom control ≥minimum important difference for study population, and by severity definition
| Population | n | Improved | No change | Worse | McNemar P value |
|---|---|---|---|---|---|
| Complete cohort | |||||
| All ages | 319 | 77 (24) | 148 (46) | 94 (29) | .14 |
| 2-4 y | 60 | 19 (32) | 17 (28) | 24 (40) | .54 |
| 5+ y | 259 | 58 (22) | 131 (51) | 70 (27) | .18 |
| 5-11 y | 157 | 40 (25) | 76 (48) | 41 (26) | .71 |
| 12+ y | 102 | 18 (18) | 55 (54) | 29 (28) | .08 |
| “Persistent poor control” | |||||
| All ages | 147 | 42 (29) | 54 (37) | 51 (35) | .46 |
| 2-4 y | 45 | 17 (38) | 10 (22) | 18 (40) | .95 |
| 5+ y | 102 | 25 (25) | 44 (43) | 33 (32) | .32 |
| 5-11 y | 56 | 15 (27) | 25 (45) | 16 (29) | .83 |
| 12+ y | 46 | 10 (22) | 19 (41) | 17 (37) | .24 |
| High-dose ICS | |||||
| All ages | 127 | 35 (28) | 50 (39) | 42 (33) | .46 |
| 2-4 y | 33 | 13 (39) | 7 (21) | 13 (39) | .84 |
| 5+ y | 94 | 22 (23) | 43 (46) | 29 (31) | .26 |
| 5-11 y | 40 | 12 (30) | 19 (48) | 9 (22) | .63 |
| 12+ y | 54 | 10 (19) | 24 (44) | 20 (37) | .07 |
| “Difficult asthma” | |||||
| All ages | 90 | 34 (38) | 31 (34) | 25 (28) | .30∗ |
| 2-4 y | 37 | 15 (41) | 9 (24) | 13 (35) | .58 |
| 5+ y | 53 | 19 (36) | 22 (42) | 12 (23) | .23∗ |
| 5-11 y | 24 | 10 (42) | 9 (38) | 5 (21) | .21∗ |
| 12+ y | 29 | 9 (31) | 13 (45) | 7 (24) | .62∗ |
Values are n (%).
∗
This severity definition is partially dependent on the (c)ACT score, so this P value may be influenced by regression to the mean.