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. 2020 May 1;87(9):857–865. doi: 10.1016/j.biopsych.2019.12.010

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© 2020 Society of Biological Psychiatry.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Association of decreased intelligence polygenic risk score (PRS) with increased Huntington’s disease (HD) symptom frequency. Numbers in the box correspond to the p-value thresholds used to derive the PRS. Black line corresponds to nominally significant association (p = .05). Green line indicates associations significant after Bonferroni correction for 63 PRS-symptom comparisons (9 PRS × 7 symptoms). Blue line indicates associations significant after Bonferroni correction for 63 PRS-symptom comparisons and 6 PRS cutoffs. Note: Only symptoms with at least one p value reaching the green line are shown. VAB, violent/aggressive behavior.