Table 1.
HD Symptom Counts and Sex Differences in the 5854 Individuals With at Least One Recorded HD Symptom Diagnosis (Positive or Negative)
| Symptom | Freq, % | Male |
Female |
OR F vs. M (95% CI) | p Value (F vs. M) | ||
|---|---|---|---|---|---|---|---|
| + | − | + | − | ||||
| Depression | 66.0 | 1639 | 1120 | 2116 | 816 | 1.75 (1.57, 1.96) | <2 × 10−16 |
| Irritability | 60.3 | 1757 | 1005 | 1675 | 1252 | 0.77 (0.69, 0.85) | 8.76 × 10−7 |
| Psychosis | 10.8 | 299 | 2396 | 301 | 2562 | 0.94 (0.79, 1.12) | .485 |
| Violent/Aggressive Behavior | 31.2 | 965 | 1794 | 802 | 2107 | 0.71 (0.63, 0.79) | 1.90 × 10−9 |
| Apathy | 53.8 | 1484 | 1291 | 1581 | 1344 | 1.02 (0.92, 1.14) | .664 |
| Perseverative/Obsessive Behavior | 37.5 | 1048 | 1713 | 1076 | 1833 | 0.96 (0.86, 1.07) | .451 |
| Cognitive Impairment | 57.5 | 1583 | 1214 | 1726 | 1235 | 1.07 (0.97, 1.19) | .194 |
+/−, number of individuals of each sex with/without the symptom. Freq is the frequency of the symptom among individuals in the sample for whom a diagnosis of that symptom was recorded.
CI, confidence interval; F, female; Freq, frequency; HD, Huntington’s disease; M, male; OR, odds ratio.