Table 2.

Effect of Sex, CAG, Age at Motor Onset, Disease Duration, and Sample Collection (Enroll-HD vs. REGISTRY) on HD Symptom Frequency

HD Symptom	Sex (F vs. M)		CAG		AMO		Duration		Enroll-HD vs. REGISTRY		AUC
	OR	p Value	OR	p Value	OR	p Value	OR	p Value	OR	p Value
Depression	1.77a	8.44 × 10−23a	0.95a	7.64 × 10−5a	0.98a	6.35 × 10−6a	1.01	.0572	1.09	.198	0.592
Irritability	0.77a	2.36 × 10−6a	0.94a	1.06 × 10−5	0.98a	3.85 × 10−9a	1.02a	.000452a	1.06	.361	0.570
Psychosis	0.96	.684	1.02	.313	1.01	.334	1.06a	2.77 × 10−14a	0.88	.242	0.599
VAB	0.70a	1.04 × 10−9a	1.00	.863	0.99a	7.95 × 10−5a	1.04a	1.32 × 10−12a	0.97	.630	0.601
Apathy	1.04	.482	1.02	.156	1.00	.900	1.04a	9.84 × 10−15a	1.06	.411	0.572
POB	0.99	.865	1.02	.0603	1.00	.322	1.05a	1.28 × 10−19a	1.52a	5.72 × 10−10a	0.586
Cognitive Impairment	1.10	.0814	1.05a	8.75 × 10−5a	1.01	.112	1.10a	2.08 × 10−54a	0.96	.540	0.638

Analysis applied to 5854 individuals with at least one recorded symptom endorsement (not necessarily positive). All variables fitted simultaneously. AUC is a measure of the ability of the covariates to jointly predict symptom presence.

AMO, age at motor onset; AUC, area under the curve; F, female; HD, Huntington’s disease; M, male; OR, odds ratio; POB, perseverative/obsessive behavior; VAB, violent/aggressive behavior.

^aStatistically significant association.