. 2020 May 1;87(9):857–865. doi: 10.1016/j.biopsych.2019.12.010

Table 3.

Logistic Regression of Symptom on Multiple PRS Simultaneously, Correcting for the Other Symptoms

Symptom	PRS	PRS Cutoff	OR	p Value
Depression	MDD^a^,^b	0.01^a	1.14^a	8.52 × 10⁻⁵^a
	Schizophrenia^b	0.05	1.04	.253
	BPD^b	0.01	1.07	.0617
	Intelligence	0.001	0.99	.679
Irritability	Schizophrenia^a^,^b	0.05^a	1.09^a	.0164^a
	MDD^b	0.001	1.07	.117
	Intelligence	1	0.97	.384
Psychosis	Schizophrenia^a^,^b	0.001^a	1.14^a	.00688^a
	MDD	0.05	1.05	.302
	Alzheimer’s^a	0.001^a	1.13^a	.0139^a
	Intelligence	0.0001	0.95	.296
VAB	Intelligence	0.01	0.93	.0630
	Schizophrenia^b	0.05	1.03	.480
	MDD	0.001	1.04	.272
	BPD^a	0.001^a	1.14^a	9.11 × 10⁻⁴^a
	ADHD^b	0.05	1.05	.209
	ASD	0.01	1.04	.262
POB	Schizophrenia	0.01	1.03	.446
	BPD^b	0.5	1.06	.0725
	Intelligence	0.01	0.97	.393
	MDD	0.5	1.01	.783
	OCD	0.001	1.07	.0532
Apathy	Intelligence	1	0.95	.137
	MDD^b	0.05	1.00	.980
	BPD	0.001	1.05	.110
	Schizophrenia^b	0.0001	1.03	.380
	ASD	0.001	1.06	.0808
Cognitive Impairment	Intelligence^a^,^b	0.01^a	0.91^a	.00411^a
	Parkinson’s^a^,^b	0.0001^a	1.10^a	.00355^a
	MDD	0.5	1.03	.319

Symptom-PRS pairs included in the analysis if they reach nominal significance (p < .05) when analyzed alone. The PRS cutoff giving the most significant association was used.

ADHD, attention-deficit/hyperactivity disorder; ASD, autism spectrum disorder; BPD, bipolar disorder; MDD, major depressive disorder; OCD, obsessive-compulsive disorder; OR, odds ratio; POB, perseverative/obsessive behavior; PRS, polygenic risk score; VAB, violent/aggressive behavior.

Symptom-PRS pairs shown reach nominal significance (p < .05) after correction both for the other PRS shown in the table and for the other symptoms.

Primary symptom-PRS hypotheses (see text).