Comparison 2. Captopril vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in SBP	5		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 37.5 mg	1	111	Mean Difference (IV, Fixed, 95% CI)	‐8.6 [‐14.95, ‐2.25]
1.2 50 mg	3	324	Mean Difference (IV, Fixed, 95% CI)	‐8.25 [‐11.34, ‐5.16]
1.3 75 mg	2	124	Mean Difference (IV, Fixed, 95% CI)	‐9.16 [‐15.09, ‐3.23]
1.4 100 mg	1	96	Mean Difference (IV, Fixed, 95% CI)	‐12.0 [‐18.17, ‐5.83]
1.5 150 mg (Max Dose)	1	117	Mean Difference (IV, Fixed, 95% CI)	‐12.0 [‐18.06, ‐5.94]
1.6 200 mg	1	94	Mean Difference (IV, Fixed, 95% CI)	‐12.20 [‐18.32, ‐6.08]
2 Change in DBP	6		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 37.5 mg	1	111	Mean Difference (IV, Fixed, 95% CI)	‐5.40 [‐8.74, ‐2.06]
2.2 50 mg	4	500	Mean Difference (IV, Fixed, 95% CI)	‐4.58 [‐6.02, ‐3.15]
2.3 75 mg	2	124	Mean Difference (IV, Fixed, 95% CI)	‐5.92 [‐9.16, ‐2.68]
2.4 100 mg	1	97	Mean Difference (IV, Fixed, 95% CI)	‐6.4 [‐9.91, ‐2.89]
2.5 150 mg (Max Dose)	1	117	Mean Difference (IV, Fixed, 95% CI)	‐7.3 [‐10.43, ‐4.17]
2.6 200 mg	1	94	Mean Difference (IV, Fixed, 95% CI)	‐6.70 [‐10.23, ‐3.17]