Comparison 3. Cilazapril vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	9		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 2.5 mg	9	361	Mean Difference (IV, Fixed, 95% CI)	‐5.16 [‐8.32, 0.00]
1.2 5 mg	5	277	Mean Difference (IV, Fixed, 95% CI)	‐5.75 [‐9.38, ‐2.12]
1.3 10 mg (Max Dose)	1	67	Mean Difference (IV, Fixed, 95% CI)	‐7.0 [‐14.07, 0.07]
2 Change in trough DBP	14		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 0.5 mg	1	129	Mean Difference (IV, Fixed, 95% CI)	‐0.5 [‐3.45, 2.45]
2.2 1 mg	1	56	Mean Difference (IV, Fixed, 95% CI)	1.1 [‐3.66, 5.86]
2.3 2.5 mg	13	558	Mean Difference (IV, Fixed, 95% CI)	‐3.32 [‐4.70, ‐1.94]
2.4 5 mg	9	569	Mean Difference (IV, Fixed, 95% CI)	‐3.49 [‐4.87, ‐2.11]
2.5 10 mg (Max Dose)	2	190	Mean Difference (IV, Fixed, 95% CI)	‐4.06 [‐6.44, ‐1.67]