Comparison 4. Enalapril vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	17		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 5 mg	4	552	Mean Difference (IV, Fixed, 95% CI)	‐5.56 [‐7.95, ‐3.18]
1.2 10 mg	8	1122	Mean Difference (IV, Fixed, 95% CI)	‐5.42 [‐5.00, ‐3.84]
1.3 20 mg	8	911	Mean Difference (IV, Fixed, 95% CI)	‐9.61 [‐11.35, ‐7.86]
2 Change in trough DBP	19		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 5 mg	5	702	Mean Difference (IV, Fixed, 95% CI)	‐2.46 [‐3.67, ‐1.25]
2.2 10 mg	8	1122	Mean Difference (IV, Fixed, 95% CI)	‐3.10 [‐3.99, ‐2.20]
2.3 20 mg	9	984	Mean Difference (IV, Fixed, 95% CI)	‐5.34 [‐6.29, ‐4.38]