Comparison 11. Ramipril vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	6		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 1.25 mg	2	98	Mean Difference (IV, Fixed, 95% CI)	4.06 [‐1.97, 10.08]
1.2 2.5 mg	4	197	Mean Difference (IV, Fixed, 95% CI)	‐4.38 [‐9.71, 0.95]
1.3 5 mg	4	195	Mean Difference (IV, Fixed, 95% CI)	‐7.47 [‐12.76, ‐2.19]
1.4 10 mg	4	257	Mean Difference (IV, Fixed, 95% CI)	‐5.74 [‐9.33, ‐2.16]
2 Change in trough DBP	6		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 1.25 mg	2	97	Mean Difference (IV, Fixed, 95% CI)	1.78 [‐1.83, 5.39]
2.2 2.5 mg	4	195	Mean Difference (IV, Fixed, 95% CI)	‐2.39 [‐5.18, 0.39]
2.3 5 mg	4	197	Mean Difference (IV, Fixed, 95% CI)	‐3.70 [‐6.38, ‐1.02]
2.4 10 mg	4	258	Mean Difference (IV, Fixed, 95% CI)	‐4.42 [‐6.54, ‐2.30]