Comparison 12. Spirapril vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	3		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 3 mg	2	130	Mean Difference (IV, Fixed, 95% CI)	‐4.09 [‐10.47, 2.29]
1.2 6 mg	3	210	Mean Difference (IV, Fixed, 95% CI)	‐7.66 [‐11.93, ‐3.40]
1.3 12 mg (Max Dose)	2	146	Mean Difference (IV, Fixed, 95% CI)	‐8.46 [‐13.27, ‐3.66]
1.4 24 mg	2	139	Mean Difference (IV, Fixed, 95% CI)	‐9.67 [‐14.39, ‐4.95]
2 Change in trough DBP	4		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 3 mg	2	130	Mean Difference (IV, Fixed, 95% CI)	‐3.91 [‐7.52, ‐0.29]
2.2 6 mg	4	359	Mean Difference (IV, Fixed, 95% CI)	‐6.52 [‐8.42, ‐4.62]
2.3 12 mg (Max Dose)	2	146	Mean Difference (IV, Fixed, 95% CI)	‐6.20 [‐9.20, ‐3.20]
2.4 24 mg	2	140	Mean Difference (IV, Fixed, 95% CI)	‐4.84 [‐7.86, ‐1.83]