Comparison 14. Trandolapril vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	10		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 0.25 mg	1	35	Mean Difference (IV, Fixed, 95% CI)	‐2.7 [‐13.26, 7.86]
1.2 0.5 mg	4	185	Mean Difference (IV, Fixed, 95% CI)	‐3.33 [‐6.00, 1.33]
1.3 1 mg	4	294	Mean Difference (IV, Fixed, 95% CI)	‐8.45 [‐11.84, ‐5.06]
1.4 2 mg	7	636	Mean Difference (IV, Fixed, 95% CI)	‐6.21 [‐8.76, ‐3.66]
1.5 4 mg (Max Dose)	3	430	Mean Difference (IV, Fixed, 95% CI)	‐8.15 [‐10.82, ‐5.49]
1.6 8 mg	2	111	Mean Difference (IV, Fixed, 95% CI)	‐5.74 [‐12.52, 1.05]
1.7 12 mg	1	49	Mean Difference (IV, Fixed, 95% CI)	‐5.7 [‐16.60, 5.20]
1.8 16 mg	1	48	Mean Difference (IV, Fixed, 95% CI)	‐7.10 [‐17.36, 3.16]
2 Change in trough DBP	10		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 0.25 mg	1	35	Mean Difference (IV, Fixed, 95% CI)	0.6 [‐4.46, 5.66]
2.2 0.5 mg	4	184	Mean Difference (IV, Fixed, 95% CI)	‐2.33 [‐4.90, 0.24]
2.3 1 mg	4	294	Mean Difference (IV, Fixed, 95% CI)	‐4.07 [‐5.89, ‐2.25]
2.4 2 mg	7	637	Mean Difference (IV, Fixed, 95% CI)	‐4.24 [‐5.55, ‐2.94]
2.5 4 mg (Max Dose)	3	431	Mean Difference (IV, Fixed, 95% CI)	‐4.62 [‐6.10, ‐3.13]
2.6 8 mg	2	110	Mean Difference (IV, Fixed, 95% CI)	‐4.41 [‐7.82, ‐1.01]
2.7 12 mg	1	49	Mean Difference (IV, Fixed, 95% CI)	‐6.2 [‐11.78, ‐0.62]
2.8 16 mg	1	48	Mean Difference (IV, Fixed, 95% CI)	‐6.2 [‐11.38, ‐1.02]