Comparison 16. 1/8 Max Dose vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	18	2025	Mean Difference (IV, Fixed, 95% CI)	‐5.70 [‐6.95, ‐4.45]
1.1 Benazepril 5 mg	2	91	Mean Difference (IV, Fixed, 95% CI)	‐6.39 [‐12.32, ‐0.47]
1.2 Enalapril 5 mg	4	607	Mean Difference (IV, Fixed, 95% CI)	‐5.12 [‐7.33, ‐2.92]
1.3 Fosinopril 5 mg	1	151	Mean Difference (IV, Fixed, 95% CI)	‐3.7 [‐8.06, 0.66]
1.4 Lisinopril 10 mg	4	648	Mean Difference (IV, Fixed, 95% CI)	‐7.75 [‐9.98, ‐5.51]
1.5 Ramipril 2.5 mg	4	292	Mean Difference (IV, Fixed, 95% CI)	‐4.52 [‐8.05, ‐0.98]
1.6 Trandolapril 0.5 mg	3	236	Mean Difference (IV, Fixed, 95% CI)	‐4.19 [‐7.91, ‐0.46]
2 Change in trough DBP	19	2176	Mean Difference (IV, Fixed, 95% CI)	‐3.19 [‐3.88, ‐2.51]
2.1 Benazepril 5 mg	2	91	Mean Difference (IV, Fixed, 95% CI)	‐1.92 [‐5.89, 2.05]
2.2 Enalapril 5 mg	5	758	Mean Difference (IV, Fixed, 95% CI)	‐2.37 [‐3.52, ‐1.23]
2.3 Fosinopril 5 mg	1	151	Mean Difference (IV, Fixed, 95% CI)	‐3.20 [‐5.72, ‐0.68]
2.4 Lisinopril 10 mg	4	648	Mean Difference (IV, Fixed, 95% CI)	‐4.71 [‐5.92, ‐3.50]
2.5 Ramipril 2.5 mg	4	292	Mean Difference (IV, Fixed, 95% CI)	‐2.50 [‐4.50, ‐0.51]
2.6 Trandolapril 0.5 mg	3	236	Mean Difference (IV, Fixed, 95% CI)	‐2.46 [‐4.59, ‐0.33]