Comparison 17. 1/4 Max Dose vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	40	3523	Mean Difference (IV, Fixed, 95% CI)	‐5.14 [‐6.05, ‐4.22]
1.1 Benazepril 10 mg	3	314	Mean Difference (IV, Fixed, 95% CI)	‐2.88 [‐5.92, 0.15]
1.2 Cilazapril 2.5 mg	9	462	Mean Difference (IV, Fixed, 95% CI)	‐4.76 [‐7.34, ‐2.18]
1.3 Enalapril 10 mg	8	1138	Mean Difference (IV, Fixed, 95% CI)	‐5.40 [‐6.93, ‐3.87]
1.4 Fosinopril 10 mg	3	239	Mean Difference (IV, Fixed, 95% CI)	‐3.93 [‐7.39, ‐0.46]
1.5 Imidapril 5 mg	1	68	Mean Difference (IV, Fixed, 95% CI)	‐4.90 [‐11.31, 1.51]
1.6 Lisinopril 20 mg	1	80	Mean Difference (IV, Fixed, 95% CI)	‐7.8 [‐14.38, ‐1.22]
1.7 Moexipril 7.5 mg	3	223	Mean Difference (IV, Fixed, 95% CI)	‐1.86 [‐5.86, 2.14]
1.8 Perindopril 2 mg	2	134	Mean Difference (IV, Fixed, 95% CI)	‐3.02 [‐9.36, 3.31]
1.9 Ramipril 5 mg	4	291	Mean Difference (IV, Fixed, 95% CI)	‐7.19 [‐10.71, ‐3.67]
1.10 Spirapril 3 mg	2	184	Mean Difference (IV, Fixed, 95% CI)	‐4.02 [‐8.33, 0.28]
1.11 Trandolapril 1 mg	4	390	Mean Difference (IV, Fixed, 95% CI)	‐7.74 [‐10.34, ‐5.15]
2 Change in trough DBP	43	3758	Mean Difference (IV, Fixed, 95% CI)	‐3.04 [‐3.53, ‐2.54]
2.1 Benazepril 10 mg	3	314	Mean Difference (IV, Fixed, 95% CI)	‐0.89 [‐2.70, 0.93]
2.2 Cilazapril 2.5 mg	12	697	Mean Difference (IV, Fixed, 95% CI)	‐3.15 [‐4.29, 0.00]
2.3 Enalapril 10 mg	8	1138	Mean Difference (IV, Fixed, 95% CI)	‐3.11 [‐2.00, ‐2.23]
2.4 Fosinopril 10 mg	3	239	Mean Difference (IV, Fixed, 95% CI)	‐3.42 [‐5.43, ‐1.42]
2.5 Imidapril 5 mg	1	68	Mean Difference (IV, Fixed, 95% CI)	‐3.2 [‐7.41, 1.01]
2.6 Lisinopril 20 mg	1	80	Mean Difference (IV, Fixed, 95% CI)	‐4.6 [‐8.63, ‐0.57]
2.7 Moexipril 7.5 mg	3	223	Mean Difference (IV, Fixed, 95% CI)	‐2.18 [‐4.11, ‐0.24]
2.8 Perindopril 2 mg	2	134	Mean Difference (IV, Fixed, 95% CI)	‐2.31 [‐5.06, 0.45]
2.9 Ramipril 5 mg	4	291	Mean Difference (IV, Fixed, 95% CI)	‐3.65 [‐5.62, ‐1.67]
2.10 Spirapril 3 mg	2	184	Mean Difference (IV, Fixed, 95% CI)	‐4.20 [‐6.66, ‐1.74]
2.11 Trandolapril 1 mg	4	390	Mean Difference (IV, Fixed, 95% CI)	‐3.52 [‐4.92, ‐2.11]