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. 2008 Oct 8;2008(4):CD003823. doi: 10.1002/14651858.CD003823.pub2

Comparison 18. 1/2 Max Dose vs Placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Change in trough SBP 51 4980 Mean Difference (IV, Fixed, 95% CI) ‐7.60 [‐8.40, ‐6.79]
1.1 Benazepril 20 mg 6 504 Mean Difference (IV, Fixed, 95% CI) ‐7.97 [‐10.41, ‐5.52]
1.2 Cilazapril 5 mg 5 379 Mean Difference (IV, Fixed, 95% CI) ‐5.92 [‐8.70, ‐3.14]
1.3 Enalapril 20 mg 8 967 Mean Difference (IV, Fixed, 95% CI) ‐9.54 [‐11.22, ‐7.86]
1.4 Fosinopril 20 mg 5 277 Mean Difference (IV, Fixed, 95% CI) ‐8.99 [‐12.35, ‐5.62]
1.5 Imidapril 10 mg 1 66 Mean Difference (IV, Fixed, 95% CI) ‐8.90 [‐16.26, ‐1.54]
1.6 Lisinopril 40 mg 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.7 Moexipril 15 mg 4 321 Mean Difference (IV, Fixed, 95% CI) ‐8.02 [‐11.16, ‐4.88]
1.8 Perindopril 4 mg 6 868 Mean Difference (IV, Fixed, 95% CI) ‐6.53 [‐9.04, ‐4.02]
1.9 Quinapril 20 mg 2 182 Mean Difference (IV, Fixed, 95% CI) ‐7.05 [‐11.26, ‐2.84]
1.10 Ramipril 10 mg 4 344 Mean Difference (IV, Fixed, 95% CI) ‐6.17 [‐9.07, ‐3.27]
1.11 Spirapril 6 mg 3 303 Mean Difference (IV, Fixed, 95% CI) ‐7.43 [‐10.41, ‐4.46]
1.12 Trandolapril 2 mg 7 769 Mean Difference (IV, Fixed, 95% CI) ‐6.17 [‐8.24, ‐4.10]
2 Change in trough DBP 57 5623 Mean Difference (IV, Fixed, 95% CI) ‐4.67 [‐5.09, ‐4.25]
2.1 Benazepril 20 mg 6 504 Mean Difference (IV, Fixed, 95% CI) ‐4.30 [‐5.70, ‐2.90]
2.2 Cilazapril 5 mg 9 800 Mean Difference (IV, Fixed, 95% CI) ‐3.40 [‐4.45, ‐2.36]
2.3 Enalapril 20 mg 9 1039 Mean Difference (IV, Fixed, 95% CI) ‐5.29 [‐6.22, ‐4.37]
2.4 Fosinopril 20 mg 5 277 Mean Difference (IV, Fixed, 95% CI) ‐6.86 [‐8.70, ‐5.02]
2.5 Imidapril 10 mg 1 66 Mean Difference (IV, Fixed, 95% CI) ‐7.40 [‐12.13, ‐2.67]
2.6 Lisinopril 40 mg 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.7 Moexipril 15 mg 4 321 Mean Difference (IV, Fixed, 95% CI) ‐4.26 [‐5.93, ‐2.60]
2.8 Perindopril 4 mg 6 868 Mean Difference (IV, Fixed, 95% CI) ‐4.81 [‐6.04, ‐3.58]
2.9 Quinapril 20 mg 2 182 Mean Difference (IV, Fixed, 95% CI) ‐3.35 [‐5.98, ‐0.72]
2.10 Ramipril 10 mg 4 344 Mean Difference (IV, Fixed, 95% CI) ‐4.47 [‐6.17, ‐2.76]
2.11 Spirapril 6 mg 4 453 Mean Difference (IV, Fixed, 95% CI) ‐5.92 [‐7.45, ‐4.39]
2.12 Trandolapril 2 mg 7 769 Mean Difference (IV, Fixed, 95% CI) ‐4.24 [‐5.35, ‐3.14]