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. 2008 Oct 8;2008(4):CD003823. doi: 10.1002/14651858.CD003823.pub2

Comparison 19. Max Dose vs Placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Change in trough SBP 16 1450 Mean Difference (IV, Fixed, 95% CI) ‐8.48 [‐9.91, ‐7.06]
1.1 Benazepril 40 mg 2 112 Mean Difference (IV, Fixed, 95% CI) ‐8.67 [‐13.73, ‐3.62]
1.2 Cilazapril 10 mg 1 101 Mean Difference (IV, Fixed, 95% CI) ‐7.0 [‐11.99, ‐2.01]
1.3 Enalapril 40 mg 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.4 Fosinopril 40 mg 3 245 Mean Difference (IV, Fixed, 95% CI) ‐7.78 [‐11.20, ‐4.36]
1.5 Imidapril 20 mg 1 66 Mean Difference (IV, Fixed, 95% CI) ‐12.90 [‐20.56, ‐5.24]
1.6 Lisinopril 80 mg 1 79 Mean Difference (IV, Fixed, 95% CI) ‐13.8 [‐20.77, ‐6.83]
1.7 Moexipril 30 mg 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.8 Perindopril 8 mg 2 129 Mean Difference (IV, Fixed, 95% CI) ‐10.09 [‐16.14, ‐4.05]
1.9 Quinapril 40 mg 1 14 Mean Difference (IV, Fixed, 95% CI) ‐6.0 [‐20.16, 8.16]
1.10 Ramipril 20 mg 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.11 Spirapril 12 mg 2 226 Mean Difference (IV, Fixed, 95% CI) ‐8.23 [‐11.65, ‐4.82]
1.12 Trandolapril 4 mg 3 478 Mean Difference (IV, Fixed, 95% CI) ‐6.00 [‐10.41, ‐5.59]
2 Change in trough DBP 17 1636 Mean Difference (IV, Fixed, 95% CI) ‐4.95 [‐5.71, ‐4.20]
2.1 Benazepril 40 mg 2 112 Mean Difference (IV, Fixed, 95% CI) ‐4.76 [‐7.84, ‐1.69]
2.2 Cilazapril 10 mg 2 287 Mean Difference (IV, Fixed, 95% CI) ‐4.06 [‐5.74, ‐2.37]
2.3 Enalapril 40 mg 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.4 Fosinopril 40 mg 3 245 Mean Difference (IV, Fixed, 95% CI) ‐4.63 [‐6.61, ‐2.65]
2.5 Imidapril 20 mg 1 66 Mean Difference (IV, Fixed, 95% CI) ‐6.3 [‐10.88, ‐1.72]
2.6 Lisinopril 80 mg 1 79 Mean Difference (IV, Fixed, 95% CI) ‐6.00 [‐9.96, ‐2.04]
2.7 Moexipril 30 mg 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.8 Perindopril 8 mg 2 129 Mean Difference (IV, Fixed, 95% CI) ‐5.94 [‐8.81, ‐3.07]
2.9 Quinapril 40 mg 1 14 Mean Difference (IV, Fixed, 95% CI) ‐9.0 [‐17.78, ‐0.22]
2.10 Ramipril 20 mg 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.11 Spirapril 12 mg 2 226 Mean Difference (IV, Fixed, 95% CI) ‐6.02 [‐8.09, ‐3.96]
2.12 Trandolapril 4 mg 3 478 Mean Difference (IV, Fixed, 95% CI) ‐4.71 [‐6.05, ‐3.37]