Comparison 20. 2 Max and Higher Doses vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	7	738	Mean Difference (IV, Fixed, 95% CI)	‐8.81 [‐10.92, ‐6.70]
1.1 Benazepril 80 mg	1	77	Mean Difference (IV, Fixed, 95% CI)	‐11.40 [‐17.51, ‐5.29]
1.2 Imidapril 40 mg	1	67	Mean Difference (IV, Fixed, 95% CI)	‐10.60 [‐17.40, ‐3.80]
1.3 Perindopril 16 mg	1	108	Mean Difference (IV, Fixed, 95% CI)	‐8.9 [‐15.36, ‐2.44]
1.4 Spirapril 24 mg	2	220	Mean Difference (IV, Fixed, 95% CI)	‐9.40 [‐12.67, ‐6.12]
1.5 Trandolapril 8, 12, 16 mg	2	266	Mean Difference (IV, Fixed, 95% CI)	‐6.03 [‐10.14, ‐1.93]
2 Change in trough DBP	7	738	Mean Difference (IV, Fixed, 95% CI)	‐5.25 [‐6.45, ‐4.05]
2.1 Benazepril 80 mg	1	77	Mean Difference (IV, Fixed, 95% CI)	‐6.80 [‐10.34, ‐3.26]
2.2 Imidapril 40 mg	1	67	Mean Difference (IV, Fixed, 95% CI)	‐6.5 [‐11.22, ‐1.78]
2.3 Perindopril 16 mg	1	108	Mean Difference (IV, Fixed, 95% CI)	‐5.5 [‐8.48, ‐2.52]
2.4 Spirapril 24 mg	2	220	Mean Difference (IV, Fixed, 95% CI)	‐4.56 [‐6.66, ‐2.47]
2.5 Trandolapril 8, 12, 16 mg	2	266	Mean Difference (IV, Fixed, 95% CI)	‐5.02 [‐7.12, ‐2.93]