Comparison 21. 1/2 Max and Higher Doses vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	53	6113	Mean Difference (IV, Fixed, 95% CI)	‐7.85 [‐8.60, ‐7.09]
1.1 Benazepril 20, 40, 80 mg	6	598	Mean Difference (IV, Fixed, 95% CI)	‐8.54 [‐10.87, ‐6.21]
1.2 Cilazapril 5, 10 mg	5	429	Mean Difference (IV, Fixed, 95% CI)	‐5.79 [‐8.46, ‐3.12]
1.3 Enalapril 20, (40) mg	8	967	Mean Difference (IV, Fixed, 95% CI)	‐9.54 [‐11.22, ‐7.86]
1.4 Fosinopril 20, 40 mg	4	359	Mean Difference (IV, Fixed, 95% CI)	‐7.44 [‐10.44, ‐4.44]
1.5 Imidapril 10, 20, 40 mg	1	129	Mean Difference (IV, Fixed, 95% CI)	‐10.8 [‐16.60, ‐5.00]
1.6 Lisinopril (40), 80 mg	1	50	Mean Difference (IV, Fixed, 95% CI)	‐13.8 [‐24.46, ‐3.14]
1.7 Moexipril 15, (30) mg	4	321	Mean Difference (IV, Fixed, 95% CI)	‐8.02 [‐11.16, ‐4.88]
1.8 Perindopril 4, 8, 16 mg	6	985	Mean Difference (IV, Fixed, 95% CI)	‐7.12 [‐9.55, ‐4.70]
1.9 Quinapril 20, (40) mg	2	182	Mean Difference (IV, Fixed, 95% CI)	‐7.05 [‐11.26, ‐2.84]
1.10 Ramipril 10, (20) mg	4	257	Mean Difference (IV, Fixed, 95% CI)	‐5.74 [‐9.33, ‐2.16]
1.11 Spirapril 6, 12, 24 mg	3	521	Mean Difference (IV, Fixed, 95% CI)	‐8.31 [‐10.80, ‐5.82]
1.12 Trandolapril 2, 4, 8, 12, 16 mg	9	1315	Mean Difference (IV, Fixed, 95% CI)	‐7.02 [‐8.70, ‐5.34]
2 Change in trough DBP	59	6861	Mean Difference (IV, Fixed, 95% CI)	‐4.73 [‐5.13, ‐4.34]
2.1 Benazepril 20, 40, 80 mg	6	598	Mean Difference (IV, Fixed, 95% CI)	‐4.56 [‐5.91, ‐3.22]
2.2 Cilazapril 5, 10 mg	9	942	Mean Difference (IV, Fixed, 95% CI)	‐3.58 [‐4.57, ‐2.60]
2.3 Enalapril 20, (40) mg	9	1039	Mean Difference (IV, Fixed, 95% CI)	‐5.29 [‐6.22, ‐4.37]
2.4 Fosinopril 20, 40 mg	4	359	Mean Difference (IV, Fixed, 95% CI)	‐5.15 [‐6.85, ‐3.45]
2.5 Imidapril 10, 20, 40 mg	1	129	Mean Difference (IV, Fixed, 95% CI)	‐6.7 [‐10.54, ‐2.86]
2.6 Lisinopril (40), 80 mg	1	79	Mean Difference (IV, Fixed, 95% CI)	‐6.00 [‐9.96, ‐2.04]
2.7 Moexipril 15, (30) mg	4	321	Mean Difference (IV, Fixed, 95% CI)	‐4.26 [‐5.93, ‐2.60]
2.8 Perindopril 4, 8, 16 mg	6	985	Mean Difference (IV, Fixed, 95% CI)	‐5.01 [‐6.18, ‐3.84]
2.9 Quinapril 20, (40) mg	2	182	Mean Difference (IV, Fixed, 95% CI)	‐3.35 [‐5.98, ‐0.72]
2.10 Ramipril 10, (20) mg	4	257	Mean Difference (IV, Fixed, 95% CI)	‐4.42 [‐6.55, ‐2.29]
2.11 Spirapril 6, 12, 24 mg	4	671	Mean Difference (IV, Fixed, 95% CI)	‐5.84 [‐7.19, ‐4.49]
2.12 Trandolapril 2, 4, 8, 12, 16 mg	9	1299	Mean Difference (IV, Fixed, 95% CI)	‐4.65 [‐5.55, ‐3.74]