Comparison 22. ACE Inhibitors vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in peak SBP [1/2 Max and Higher Doses Only]	11	1154	Mean Difference (IV, Fixed, 95% CI)	‐11.53 [‐13.27, ‐9.78]
1.1 1/2 Max Dose	11	783	Mean Difference (IV, Fixed, 95% CI)	‐11.06 [‐13.11, ‐9.02]
1.2 Max Dose	3	143	Mean Difference (IV, Fixed, 95% CI)	‐11.48 [‐17.37, ‐5.60]
1.3 2 Max Dose	3	228	Mean Difference (IV, Fixed, 95% CI)	‐13.36 [‐17.40, ‐9.31]
2 Change in peak DBP [1/2 Max and Higher Doses Only]	15	1485	Mean Difference (IV, Fixed, 95% CI)	‐6.37 [‐7.15, ‐5.58]
2.1 1/2 Max Dose	15	1103	Mean Difference (IV, Fixed, 95% CI)	‐6.02 [‐6.95, ‐5.08]
2.2 Max Dose	4	157	Mean Difference (IV, Fixed, 95% CI)	‐6.49 [‐8.81, ‐4.16]
2.3 2 Max Dose	3	225	Mean Difference (IV, Fixed, 95% CI)	‐7.69 [‐9.56, ‐5.82]
3 Change in peak SBP [All Doses]	11		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 1/8 Max Dose	1	11	Mean Difference (IV, Fixed, 95% CI)	‐11.3 [‐30.46, 7.86]
3.2 1/4 Max Dose	6	326	Mean Difference (IV, Fixed, 95% CI)	‐6.03 [‐9.93, ‐2.13]
3.3 1/2 Max Dose	11	724	Mean Difference (IV, Fixed, 95% CI)	‐10.97 [‐13.14, ‐8.80]
3.4 Max Dose	3	136	Mean Difference (IV, Fixed, 95% CI)	‐11.43 [‐17.69, ‐5.16]
3.5 2 Max Dose	3	211	Mean Difference (IV, Fixed, 95% CI)	‐13.58 [‐18.03, ‐9.13]
4 Change in peak DBP [All Doses]	15		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 1/8 Max Dose	3	154	Mean Difference (IV, Fixed, 95% CI)	‐9.51 [‐12.64, ‐6.38]
4.2 1/4 Max Dose	9	451	Mean Difference (IV, Fixed, 95% CI)	‐3.69 [‐5.24, ‐2.15]
4.3 1/2 Max Dose	15	981	Mean Difference (IV, Fixed, 95% CI)	‐5.98 [‐7.02, ‐4.94]
4.4 Max Dose	4	157	Mean Difference (IV, Fixed, 95% CI)	‐6.49 [‐8.81, ‐4.16]
4.5 2 Max Dose	3	212	Mean Difference (IV, Fixed, 95% CI)	‐7.78 [‐9.74, ‐5.83]
5 Change in trough heart rate	16		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.1 1/8 Max Dose	1	114	Mean Difference (IV, Fixed, 95% CI)	‐3.0 [‐6.62, 0.62]
5.2 1/4 Max Dose	10	587	Mean Difference (IV, Fixed, 95% CI)	‐0.47 [‐1.76, 0.81]
5.3 1/2 Max Dose	9	917	Mean Difference (IV, Fixed, 95% CI)	‐0.71 [‐1.99, 0.57]
5.4 Max Dose	2	89	Mean Difference (IV, Fixed, 95% CI)	1.31 [‐2.15, 4.76]
6 Total withdrawals due to adverse effects	56		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 1/16 Max Dose	4	282	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.39, 2.57]
6.2 1/8 Max Dose	9	842	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.42, 1.82]
6.3 1/4 Max Dose	32	3385	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.42, 1.00]
6.4 1/2 Max Dose	38	3568	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.55, 1.19]
6.5 Max Dose	8	840	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.56, 2.35]
6.6 2 Max Dose	5	567	Risk Ratio (M‐H, Fixed, 95% CI)	1.51 [0.68, 3.34]