1. Overview of the 92 included studies investigating ACE inhibitors as monotherapy.

ACE inhibitor	Dose range (mg/day)	Number of studies	ACEI patients (n)	Placebo patients (n)	Mean duration (wks)	Mean age (yrs)	Baseline BP (mm Hg)	Baseline PP (mm Hg)
Benazepril	2 ‐ 80	7	591	335	6.0	56.3	159.5/103.5	56.0
Captopril	37.5 ‐ 200	6	660	383	6.5	54.9	155.0/100.1	54.9
Cilazapril	0.5 ‐ 10	14	1054	448	4.9	53.3	153.5/101.0	52.5
Enalapril	5 ‐ 20	19	1477	1331	6.5	54.2	157.5/100.5	57.0
Fosinopril	2.5 ‐ 40	6	481	168	5.0	52.5	152.1/101.2	50.9
Imidapril	5 ‐ 40	1	127	35	4.0	51.9	160.7/101.5	59.2
Lisinopril	1.25 ‐ 80	5	484	357	5.7	55.2	154.5/101.8	52.7
Moexipril	7.5 ‐ 15	4	274	159	10.7	60.5	160.4/101.7	58.7
Perindopril	2 ‐ 16	6	658	396	7.1	55.9	159.4/99.9	59.5
Quinapril	20	3	99	97	4.0	52.6	161.7/105.6	56.1
Ramipril	1.25 ‐ 10	6	548	199	6.6	51.2	156.6/100.9	55.7
Spirapril	3 ‐24	4	586	189	5.6	52.3	164.3/103.5	60.8
Temocapril	20	1	19	11	6.0	57.0	158.0/97.6	60.4
Trandolapril	0.25 ‐ 16	10	1152	636	6.1	53.4	155.4/100.7	54.7
TOTAL		92	8210	4744	6.2	54.4	157.1/101.2	55.9