Study	Reason for exclusion
Bainbridge 1993	Crossover trial with no pre‐crossover data for first 4 weeks of treatment (ramipril 2.5 mg/day vs. placebo).
Bakris 2002	Parallel group trial with 8‐week treatment period, forced titration at 4 weeks. Pre‐titration data not reported (enalapril 10 mg/day vs. losartan 50 mg/day vs. placebo).
Beaulieu 1993	Crossover trial with no pre‐crossover data for first 4 weeks of treatment (fosinopril 20 mg/day vs. placebo).
Bergstrand 1985	Balanced, two‐period, incomplete‐block design with 2 treatment periods of 3‐weeks duration. First treatment period data not reported (enalapril 2.5, 5, 10, 20, 40 vs. placebo).
Bohlen 1996	Parallel group trial with 6‐week treatment period, titration in non‐responders at 4 weeks. Pre‐titration data not reported (perindopril 4 mg/day vs. placebo).
Canter 1994	Parallel group trial with 8‐week treatment period. Number of patients per treatment arm not reported (quinapril 2.5, 10, 40 mg/day vs. placebo).
Canter 1994a	Crossover trial with no pre‐crossover data for first 4 weeks of treatment (quniapril 20 mg/day vs. placebo).
Cleroux 1994	Crossover trial with no pre‐crossover data for first 4 weeks of treatment. 8‐week treatment periods but titration in non‐responders after 4 weeks treatment (quinapril 10 mg/day vs. placebo).
Cuspidi 1997	Crossover trial with no pre‐crossover data for first 4 weeks of treatment (lisinopril 20 mg/day vs. placebo).
Duprez 1986	Crossover trial with no pre‐crossover data for first 6 weeks of treatment (enalapril 20 mg/day vs. placebo).
Fagard 2001	Crossover trial with no pre‐crossover data reported for first 6 weeks of treatment (enalapril 20 mg/day vs. losartan 50 mg/day vs. placebo).
Gall 1992	Crossover trial with no pre‐crossover data for first 4 weeks of treatment. 8‐week treatment periods but titration in non‐responders after 4 weeks treatment (captopril 50 mg/day vs. placebo).
Gans 1993	Parallel group trial with 8‐week treatment period, titration in non‐responders at 4 weeks. Pre‐titration data not reported (cilazapril 2.5 mg/day vs. placebo).
Gleerup 1996	Crossover trial with no pre‐crossover data reported for first 4 weeks of treatment (spirapril 6 mg/day vs. placebo).
Guitard 1994a	Crossover trial with no pre‐crossover data reported for first 3 weeks of treatment (spirapril 3, 6, 12, 24 mg/day vs. placebo).
Gupta 1990	Crossover trial with no pre‐crossover data for first 4 weeks of treatment (quinapril 40 mg/day vs. placebo).
Homuth 1993a	Parallel group trial with 6‐week treatment period. BP data not extractable from figures (ramipril 2.5, 10, 20 mg/day vs. placebo).
Hu 1999	Parallel group trial with 12‐week treatment period, titration in non‐responders every 4 weeks. Pre‐titration data not reported (captopril 50 mg/day vs. placebo).
Kahan 1999	Crossover trial with no pre‐crossover data reported for first 6 weeks of treatment (ramipril 5 mg/day vs. placebo).
Karlberg 1987	Parallel group trial with 4‐week treatment period. BP data for placebo group not reported at week 4 (ramipril 5 mg/day vs. ramipril 10 mg/day vs. placebo).
Kjeldsen 1992	Crossover trial with no pre‐crossover data reported for first 4 weeks of treatment (quinapril 40 mg/day vs. placebo).
Lacourciere 1999	Parallel group trial with 8‐week treatment period. BP data for placebo group not reported (lisinopril 20 mg/day vs. telmisartan 80 mg/day vs. placebo).
Lavezzaro 1990	Crossover trial with no pre‐crossover data reported for first 4 weeks of treatment (captopril 100 mg/day vs. placebo).
Leonetti 1991	Parallel group trial with 8‐week treatment period, titration in non‐responders at 4 weeks. Pre‐titration data not reported (captopril 50 mg/day vs. placebo).
Littler 1990	Crossover trial with no pre‐crossover data reported for first 6 weeks of treatment (perindopril 8 mg/day vs. placebo).
Louis 1992	Parallel group trial with 4‐week treatment period. Only maximum BP reduction is reported (perindopril 2, 4, 8 mg/day vs. placebo).
Miyajima 1999	Parallel group trial with 12‐week treatment period, titration in non‐responders at 4 weeks. Pre‐titration data not reported (imidapril 5 mg/day vs. placebo).
Morgan 2001	Crossover trial with no pre‐crossover data for first 4 weeks of treatment. 8‐week treatment periods but titration in non‐responders after 4 weeks treatment (enalapril 20 mg/day vs. perindopril 4 mg/day vs. placebo).
Petersen 1996	Crossover trial with no pre‐crossover data reported for first 4 weeks of treatment (spirapril 24 mg/day vs. placebo).
Petrie 2000	Crossover trial with no pre‐crossover data reported for first 4 weeks of treatment (trandolapril 2 mg/day vs. placebo).
Petrov 2001	Crossover trial with no pre‐crossover data reported for first 6 weeks of treatment (enalapril 20 mg/day vs. losartan 50 mg/day vs. placebo).
Plouin 1991	Parallel group trial with 8‐week treatment period, titration in non‐responders at 4 weeks. Pre‐titration data not reported (perindopril 4 mg/day vs. placebo).
Pritchard 1996	Crossover trial with no pre‐crossover data reported for first 3 weeks of treatment (trandolapril 2 mg/day vs. placebo).
Reisin 1997	Parallel group trial with 12‐week treatment period, titration in non‐responders every 4 weeks. Pre‐titration data not reported (lisinopril 10 mg/day vs. placebo).
Salvetti 1987	Crossover trial with no baseline data and no pre‐crossover data reported for first 4 weeks of captopril 100 mg/day vs. placebo. Only mean arterial blood pressure values given.
Salvetti 1988	Crossover trial with no pre‐crossover data reported for first 4 weeks of treatment (captopril 50, 100 mg/day vs. placebo).
Salvetti 1989	Crossover trial with no pre‐crossover data reported for first 4 weeks of treatment (enalapril 10, 20, 40 mg/day vs. placebo).
Samuelsson 1992	Parallel group trial with 8‐week treatment period, titration in non‐responders at 2 or 4 weeks. Pre‐titration data not reported (lisinopril 20 mg/day vs. placebo).
Sassano 1984a	Parallel group trial with 6‐month treatment period. Additional BP lowering drugs added to enalapril 20 mg in non‐responders at 4 weeks. Data during first 4 weeks not reported.
Scholze 1993	Parallel group trial with 6‐week treatment period. Number of patients per treatment arm not reported (ramipril 2.5, 5, 10 mg/day vs. placebo).
Thurig 1995	Crossover trial with no pre‐crossover data reported for first 8 weeks of treatment (lisinopril 20 mg/day vs. placebo).
Tomei 1992	Crossover trial with no pre‐crossover data reported for first 4 weeks of treatment (lisinopril 20 mg/day vs. placebo).
Wiggam 1998	Crossover trial with no pre‐crossover data reported for first 8 weeks of treatment (captopril 100 mg/day vs. placebo).
Wilkins 1983	Parallel group trial with 12‐week treatment period, titration in non‐responders every 4 weeks. Pre‐titration data not reported (enalapril 10 mg/day vs. placebo).
Wing 1987	Crossover trial with no pre‐crossover data reported for first 4 weeks of treatment (enalapril 20 mg/day vs. placebo).
Wing 1988	Crossover trial with no pre‐crossover data reported for first 4 weeks of treatment (enalapril 20 mg/day vs. placebo).
Youssef 1993	Parallel group trial with 8‐week treatment. Highly suspicious data (enalapril 20 mg/day vs. benazepril 10 mg/day vs. placebo).
Zanchetti 2001	Parallel group trial with 8‐week treatment period, titration in non‐responders at 4 weeks. Pre‐titration data not reported (enalapril 10 mg/day vs. candesartan 4 mg/day vs. placebo).