Scholze 1999.

Methods	2‐ to 4‐week single‐blind placebo run‐in; inclusion criteria= supine DBP 100‐115 mm Hg after run‐in; 6‐week double‐blind treatment
Participants	All patients: n=507(327 males,180 females); mean age=50.2 years; baseline SBP/DBP not reported
Interventions	Ramipril 2.5 mg once daily; Ramipril 5 mg once daily; Ramipril 10 mg once daily; Placebo
Outcomes	Mean change from baseline in trough supine SBP/DBP using mercury sphygmomanometer
Notes	BP change and SEM of change reported, endpoint BP and SD not reported; calculated SD of change from N and change SE; BP data from Table 1, p. 1453; Jadad score=3; funding source= Hoechst AG
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear