| Methods |
4‐week single‐blind placebo washout; inclusion criteria= sitting DBP > 100 and < 115 mm Hg after washout; 8‐week double‐blind treatment, randomized to either placebo or quinapril 20 mg once daily for 4 weeks with optional titration to 40 mg once daily for subsequent 4 weeks based on diastolic response |
| Participants |
Quinapril: n=10; mean age=55(14.9) years; baseline SBP=161(22.2) mm Hg, DBP=105(5.6) mm Hg;
Placebo: n=11; mean age=50(9.9) years; baseline SBP=154(20.6) mm Hg, DBP=103(5.0) mm Hg |
| Interventions |
Quinapril 20 mg once daily;
Placebo |
| Outcomes |
Mean change from baseline in sitting SBP/DBP |
| Notes |
Used week 4 BP data only; BP change and SD of change reported, endpoint BP and SD reported; time of dosing not reported; time of BP measurement not reported; SBP data from Table IA, p. 321, DBP data from Table IIA, p. 323; time of BP measurement not reported; BP measurement device not reported; Jadad score=3; funding source= not reported |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
