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. 2008 Oct 8;2008(4):CD003823. doi: 10.1002/14651858.CD003823.pub2

McFate‐Smith 1991.

Methods 2‐ to 4‐week single‐blind placebo run‐in; inclusion criteria= sitting DBP 95‐115 mm Hg after run‐in; 4‐week double‐blind treatment
Participants All patients: n=202; mean age=70 years; baseline sitting SBP=177 mm Hg, DBP=103 mm Hg; 
 Benazepril 2 mg BID: n=50; 
 Benazepril 10 mg BID: n=50; 
 Placebo: n=50
Interventions Benazepril 2 mg twice daily; 
 Benazepril 10 mg twice daily; 
 Placebo
Outcomes Mean change from baseline in sitting SBP/DBP; 
 BP measured 10‐14 h post‐dose
Notes BP change reported; SD of change not reported, endpoint BP and SD not reported; imputed overall trial mean SD of change; BP data from Table 1, p. IV‐81; BP measurement device not reported; Jadad score=3; funding source= Ciba‐Geigy Inc.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear