Figure 1.

Two definitions of “nonthreatening” disease for a prostate cancer (PCa) diagnosed by prostate-specific antigen (PSA) screening. A) D’Amico classification of clinically localized PCa into low- (white), intermediate- (light gray), and high- (dark gray) risk groups. B) An overdiagnosed PCa (white) is any PCa that would not have been diagnosed during the patient’s remaining lifetime in the absence of screening.