Table 3.

Parameters (± standard error) for a nonlinear mixed-effects model for the association of log-HR for OS and log-HR for PFS

Parameter*	Estimate	Standard error
$\alpha$	0.045	0.291
$\beta$	0.425	0.805
$\mu$	−0.332	0.054
$g$	0	0.001
${\sigma }^2$	0.007	0.009

^* $\mathrm{ }\alpha$ = intercept of the linear relationship between the log-HR for OS and log-HR for PFS (when the HR for PFS is 1.0, the estimated HR for OS is e^0.045 = 1.05); $\beta$ = coefficient of the linear relationship between the log-HR for OS and log-HR for PFS; $\mu$ = average log-HR for PFS across trials; corresponding to an HR of e^−0.332 = 0.72; $g$ = variance of log-HR for OS across trials that is not explained by PFS; ${\sigma }^2$= variance of log-HR for PFS across trials. HR = hazard ratio; OS = overall survival; PFS = progression-free survival.