Table 1.
Autophagy inhibitor | Target point | Inhibition stage | References |
---|---|---|---|
3-MA | PI3K inhibition | Early | (Horwacik et al., 2015; Zhang et al., 2015) |
LY294002 | PI3K/mTOR inhibition | Early | (Feng et al., 2018; Shen et al., 2017) |
Baf A1 | Vacuolar-type H(+)-ATPase inhibition | Late | (Miyazawa, 2011) |
CQ | Lysosomal inhibition | Late | (Kimura et al., 2012; Fukuda et al., 2015; Liu et al., 2016) |
HCQ | Lysosomal inhibition | Late | (Vogl et al., 2014; Rangwala et al., 2014) |
ABT-737 | Bcl-2 inhibition | Early | (Huang and Sinicrope, 2010; Yang et al., 2016) |
Obatoclax | Lysosomal inhibition | Late | (Koehler et al., 2015; Jiménez-Guerrero et al., 2018) |
Clarithromycin | Block autophagy flux | Late | (Altman and Platanias, 2012; Sugita et al., 2015) |
Resveratrol | Autophagy regulator -S6K1 | Early | (Lin et al., 2012; Alayev et al., 2015; Rai et al., 2016) |
Quinacrine | Lysosomal inhibition | Late | (Lobo et al., 2013; Golden et al., 2015) |
4-Acetylantroquinonol B | Block autophagy flux | Late | (Liu et al., 2017) |
EGCG | Block autophagy flux | Late | (Meng et al., 2019) |
3-MA, 3-methyladenine; Baf A1, bafilomycin A1; PI3K, phosphatidylinositol 3 kinase; mTOR, mammalian target of rapamycin; CQ, chloroquine; HCQ, hydroxychloroquine; ATPase, adenosine triphosphatase; EGCG, Epigallocatechin gallate.