Table 3.

Autophagy inhibition of drugs targeting specific signaling in cancer treatment.

Drug name	Targeting signaling	Autophagy Inhibitor	Targeting Cancer cells	References
Rapamycin	mTORC1	Resveratrol	Breast cancer	(Alayev et al., 2015)
Everolimus	PI3K/AKT/mTOR	CQ	Renal cancer	(Grimaldi et al., 2015)
Simvastatin	AMPK	BafA1, 3-MA or AMPK Inhibitor	Glioblastoma	(Misirkic et al., 2012)
SKF-96365	Calcium/CaMKIIγ/AKT	HCQ	Colorectal cancer	(Jing et al., 2016)
AZD5363	AKT	BafA1, 3-MA or CQ	Prostate cancer	(Lamoureux et al., 2013)
AZ7328	AKT	CQ	Bladder cancer	(Dickstein et al., 2012)
MRK003	Notch1/γ-secretase	CQ	Glioblastoma	(Natsumeda et al., 2016)
Flavopiridol	CDK	CQ	Leukemia	(Mahoney et al., 2012)
SKF-96365	SOCE	HCQ	Colorectal cancer	(Jing et al., 2016)
Dichloroacetate	PDK	3-MA	Colorectal cancer	(Gong et al., 2013)

CQ, chloroquine; HCQ, hydroxychloroquine; 3-MA, 3-methyladenine; Baf A1, bafilomycin A1; PI3K, phosphatidylinositol 3 kinase; mTORC1, mammalian target of complex 1; Akt, protein kinase B; mTOR, mammalian target of rapamycin; AMPK, adenosine monophosphate activated protein kinase; CDK, cycling-dependent kinase; SOCE, store-operated Ca²⁺ entry; PDK, pyruvate dehydrogenase kinase.