Table 4.

Combination treatment by targeting drug-induced autophagy in clinical trials for cancer therapy.

Phase	Drug name	Targeting cancer cells	Autophagy inhibitor	References
I	Temozolomide	Melanoma and advanced solid tumors	HCQ	(Rangwala et al., 2014)
I/II	Temozolomide	Glioblastoma	HCQ	(Rosenfeld et al., 2014)
I	Doxorubicin	Advanced solid tumors	Pantoprazole	(Brana et al., 2014)
I	Doxorubicin	Lymphoma	HCQ	(Barnard et al., 2014)
I	Bortezomib	Myeloma	HCQ	(Vogl et al., 2014)
I	Temsirolimus	Melanoma	HCQ	(Rangwala et al., 2014)
I	Vorinostat	Advanced solid tumors	HCQ	(Mahalingam et al., 2014)

HCQ, hydroxychloroquine.