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. 2020 Apr 8;11:432. doi: 10.3389/fphar.2020.00432

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Copyright © 2020 Yang, Ma, Xuan, Deng, Chen and Yuan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Liraglutide ameliorates hepatic steatosis with suppressed gluconeogenesis and inflammation in non-alcoholic fatty liver disease (NAFLD) wild type (WT) mice. HE staining (A) and Oil red O staining (B) of liver tissues; Scale bars = 50 μm. (C) the statistical charts of TG content in liver tissues; (D) Serum TG concentration. (E, F) Relative mRNA expressions of fatty acid oxidation-related genes ACOX-1 (E) and CPT-1a (F) in livers were measured by quantitative PCR (qPCR). (G–J) Relative mRNA expressions of gluconeogenesis-related genes G6P (G) and PEPCK (H), as well as inflammation-related genes NF-κB (I) and IL-1β (J) in livers. (K) Serum IL-1β concentration. n=7. Data are expressed as the mean ± SD. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, and ^****P < 0.0001. Ns, no statistical difference.